Which of the following behaviors would indicate a significant change according to C1310?

The behavior that indicates a significant change according to C1310 is a patient who always appears calm suddenly exhibiting aggression. This change suggests a notable shift in the patient's emotional state and behavior, which could impact their overall health and require further assessment and intervention. A sudden display of aggression may signal underlying issues, such as anxiety, pain, or an adverse reaction to medication, necessitating prompt evaluation.

In contrast, the other behaviors do not indicate significant changes as defined by C1310. A patient who remains consistently disoriented is not exhibiting a new or changed behavior, implying stability although it may not be an ideal condition. Similarly, a consistently quiet patient becoming demanding might simply indicate a transformation within the existing pattern rather than a significant change that warrants further investigation. Lastly, a patient who was once attentive becoming withdrawn also reflects a change but may not be classified as significantly alarming as aggressive behavior, depending on individual case dynamics.